A Mini Review: Efek Farmakologi Andrographis Paniculata (Sambiloto)
Abstract
Andrographis paniculata (A. paniculata) atau sambiloto merupakan salah satu tanaman herbal yang pemanfaatannya cukup luas di masyarakat. Tumbuhan ini tumbuh baik di wilayah Asia Tenggara dan dilaporkan memiliki berbagai efek farmakologi bagi kesehatan. A. paniculata diketahui memiliki efek antikanker, antibakteri, analgetik, antidiabetik dan menurunkan tekanan darah. Akan tetapi, semua hasil penelitian ini masih terbatas pada pengujian pada hewan coba dan belum ada uji klinis yang memadai pada manusia. Data efek tanaman ini pada kesehatan reproduksi juga menunjukkan bahwa tanaman ini dapat mengganggu proses spermatogenesis sehingga dapat mengganggu kesuburan.
References
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13. Yoopan N, Thisoda P, Rangkadilok N, Sahasitiwat S, Pholphana N, Ruchirawat S, et al., Cardiovascular Effects of 14-Deoxy-11,12-didehydroandrographolide and Andrographis paniculata Extracts. Planta medica. 2007. 73:503-11.
14. Xing LF, Sheng LS. Effects of andrographolide on the activation of mitogen activated protein kinases and nuclear factor-κB in mouse peritoneal macrophage-derived foam cells. Chinese Journal of Integrative Medicine. 2012. 18(5):391–394
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16. Thakur DA, Rai G, Chatterjee S, Kumar V. Analgesic and anti-inflammatory activity of Andrographis paniculata and andrographolide in diabetic rodents. EC Pharmaceutical Science. 2015. 1. 19-28.
17. Zou W, Xiao Z, Wen X, Luo J, Chen S, Cheng Z, et al., The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway. BMC Complement Altern Med. 2016. 16: 483.
18. Liang HX , Lu SS , Yan Z, Kuang YP, Zhu XX, Yan ZG , et al., Andrographolide disrupts meiotic maturation by blocking cytoskeletal reorganisation and decreases the fertilisation potential of mouse oocytes. Reproduction, Fertility and Development.2017. 29(12) 2336-2344
19. Akbarsha MA, Murugaian P. Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa. Phytotherapy Research. 2000. 14(6): 432-435
20. Allan JJ, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A. Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats. Int J Toxicol. 2009. 28(4):308-17.
2. Mishra US, Mishra A, Kumari R, Murthy PN, Naik BS. Antibacterial Activity of Andrographis paniculata. Indian J Pharm Sci. 2009. 71(4): 436–438.
3. Singh S, Mehta A, Baweja S, Ahirwal L, Mehta P. Anticancer Activity of Andrographis paniculata and Silybum marianum on Five Human Cancer Cell Lines. Journal of Pharmacology and Toxicology. 2013. 8:42-48.
4. Hodroj MH, Jardaly A, Raad SA, Zouein A, Rizk S. Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway. Cancer Management and Research. 2018.10: 1079-1088
5. Phorutai P, Supeecha K, Seiji O, Tavan J. Andrographolide Inhibits Cholangiocarcinoma Cell Migration by Down-Regulation of Claudin-1 via the p-38 Signaling Pathway. Frontiers in Pharmacology. 2019. 10: 827 doi.org/10.3389/fphar.2019.00827
6. Rajeshkumar S, Nagalingam M, Ponnanikajamideen M, Vanaja M, Malarkodi C. Anticancer Activity Of Andrographis Paniculata Leaves Extract Against Neuroblastima (IMR-32) And Human Colon (HT-29) Cancer Cell Line. World Journal of Pharmacy and Pharmaceutical Sciences.2015. 4(6):1667-1675
7. Singha PK, Roy S, Dey S. Antimicrobial activity of Andrographis paniculata. Fitoterapia. 2003. 74(7-8):692-4
8. Roy BK, Ahmed K, Chowdhury AMS, Sarwaruddin, Rashid MA. Antidiabetic Activity of Andrographis paniculata. Dhaka University Journal of Pharmaceutical Sciences. 2007. 6.10.3329/dujps.v6i1.338.
9. Nugroho AE, Andrie M, Warditiani NK, Siswanto E, Pramono S, Lukitaningsih E. Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. Indian J Pharmacol. 2012. 44(3): 377–381.
10. Akhtar MT, Bin Mohd Sarib MS, Ismail IS, Abas F, Ismail A, Lajis NH, et al., Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats. Molecules. 2016. 21(8):1026.
11. Trilestari, Nurrochmad A, Ismiyati, Wijayanti A, Nugroho AE. Antihypertensive activity of ethanolic extract of Andrographis paniculata herbs in wistar rats with a non-invasive method. 2015. 7:247-255.
12. Zhang CY, Tan BK. Hypotensive activity of aqueous extract of Andrographis paniculata in rats. Clin Exp Pharmacol Physiol.1996 Aug;23(8):675-8.
13. Yoopan N, Thisoda P, Rangkadilok N, Sahasitiwat S, Pholphana N, Ruchirawat S, et al., Cardiovascular Effects of 14-Deoxy-11,12-didehydroandrographolide and Andrographis paniculata Extracts. Planta medica. 2007. 73:503-11.
14. Xing LF, Sheng LS. Effects of andrographolide on the activation of mitogen activated protein kinases and nuclear factor-κB in mouse peritoneal macrophage-derived foam cells. Chinese Journal of Integrative Medicine. 2012. 18(5):391–394
15. Suebsasana S, Pongnaratorn P, Sattayasai J, Arkaravichien T, Tiamkao S, Aromdee C. Analgesic, antipyretic, anti-inflammatory and toxic effects of andrographolide derivatives in experimental animals. Arch Pharm Res. 2009.32(9):1191-200.
16. Thakur DA, Rai G, Chatterjee S, Kumar V. Analgesic and anti-inflammatory activity of Andrographis paniculata and andrographolide in diabetic rodents. EC Pharmaceutical Science. 2015. 1. 19-28.
17. Zou W, Xiao Z, Wen X, Luo J, Chen S, Cheng Z, et al., The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway. BMC Complement Altern Med. 2016. 16: 483.
18. Liang HX , Lu SS , Yan Z, Kuang YP, Zhu XX, Yan ZG , et al., Andrographolide disrupts meiotic maturation by blocking cytoskeletal reorganisation and decreases the fertilisation potential of mouse oocytes. Reproduction, Fertility and Development.2017. 29(12) 2336-2344
19. Akbarsha MA, Murugaian P. Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa. Phytotherapy Research. 2000. 14(6): 432-435
20. Allan JJ, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A. Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats. Int J Toxicol. 2009. 28(4):308-17.
Published
2021-05-10
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