Case Report Diagnosis and Management of Essential Trombositosis in RSUD Sanjiwani Gianyar and RSUP Sanglah

Abstrak

Essential thrombocytosis (ET) is a very rare disorder with 1-2 / 100,000 incidents in the world. In Indonesia there is still no concrete data regarding the incidence of ET. Essential thrombocytosis can affect all ages but most at age> 60 years, with median age diagnosed ET about 65-70 years. Women are more often affected than men with a 2: 1 ratio. Patients can have hemorrhagic tendencies in the form of bleeding in the gums, epistaxis and microvascular thrombus. The diagnosis of ET can be established by WHO criteria of platelet increase> 450, in bone marrow biopsy obtained megakariocyte cells, no WHO criteria for PV, CML, MDS, or other myeloid neoplasm diseases, and clonal marker. Management of ET is done based on the consideration of the risk level of the occurrence of thrombosis complications. Risk factors for thrombosis are age, thrombosis risk, cardiovascular risk, and the presence of a JAK2 V617F mutation. Treatment of ET can use antiplatelet and cytoreductive drugs with an age-based use of indication. The results of this case report show a matching between the theory and the situation in the patient.